The G Barrington presents an interesting view, but in my view also a false dichotomy, an all or nothing approach. The GB was signed by a large number of medical experts/professionals, but there is an equally large number of medical experts/professionals who disagree with its premises. Having said that, I certainly acknowledge the social and economic difficulties caused by the lockdowns etc.
I think Fauci is doing the best he can under the circumstances here in the USA, with its fragmented and inequitable health care system.
There is much discussion about vax % of effectivity, but then one also needs to define what that % represents. As far as I know, it is not related to rates Of transmission. I get the regular flu shot ever year, knowing fully that I will not be 100% protected, but I think it at least reduces my level of risk. If the US gov't had acted differently when covid first cropped up here, we would likely be in a different situation, but that is water under the bridge.